To investigate whether the cleavage of CADM1 also occurs on NCI-H69 human SCLC cells, the cell extracts and culture media were individually collected and subjected to immunoblot analysis with a commercially available anti-CADM1 antibody that is specific to the second Ig-like domain in the ECD of CADM1. The gene discussed is CADM1; the disease is small cell lung carcinoma.