CADM1 and cancer: Variant 8/9 is susceptible to cleavage by proteases, such as a disintegrin and metalloprotease 10 (ADAM10), and γ-secretases, and it generates the membrane-bound fragment of CADM1 (MF-CADM1) on the cancer cell surface, whereas variant 8 was known to be a cleavage-resistant form of CADM1 [33].