In this case, deletion of mmp14 in adult mice fibroblast induces fibrotic skin phenotype since they are not able to process collagen type I. Moreover, bleomycin-induced experimental lung fibrosis is exacerbated by epithelial MMP-14 deficiency since it reveals abnormal proteolytic processing of ECM, a process associated with an epithelial senescence phenotype [55] related to the aggravation of fibrosis [202]. Here, MMP14 is linked to pulmonary fibrosis.