There are, at least, four reasons to support the participation of CD147 in PF: (1) Fibroblasts were firstly described as effectors of CD147 activity in the earliest Biswas’s experiments [246]; (2) as mentioned above, CD147 induces secretion of MMPs, which play a critical role in PF; (3) direct interactions of CD147 with other proteins observed in cancer are responsible for functions that also modulate fibrosis development; and (4) PF shares similarities with lung cancer progression and the presence of stroma and fibroblasts in lung cancer worsens clinical outcome [294]. This evidence concerns the gene BSG and lung cancer.