Other histological studies of IPF patients show the presence of TIMP-1 in interstitial macrophages, TIMP-2 in fibroblast foci, TIMP-3 in the elastic lamina in vessels and TIMP-4 in epithelial and plasma cells, supporting the idea that reduced collagen degradation is fundamental to this disorder [93]. The gene discussed is TIMP2; the disease is idiopathic pulmonary fibrosis.