MAPT and Alzheimer disease: Extracellular amyloid plaques, mainly formed by Aβ1-42 peptide, and intraneuronal neurofibrillary tangles, formed by phosphorylated Tau protein aggregates, are, along with cerebral amyloid angiopathy (CAA) and subsequent neuronal loss, the main neuropathological hallmarks of Alzheimer’s disease (AD) [1,2].