STX1A and hemolytic-uremic syndrome: The presence of the Stx receptor GSL Gb3Cer in lipid rafts is believed to play a key role in the pathology of HUS since binding of Stx1a and Stx2a to tissue sections of human renal glomeruli was found detergent-resistant, whereas Stx binding to renal tubules was detergent sensitive [239,240].