CCNE1 and malignant colon neoplasm: Lee et al. found that the fargesin-induced colony growth inhibition of colon cancer cells was mediated by suppression of the cyclin-dependent kinase 2 (CDK2)/cyclin E signaling axis by the upregulation of p21WAF1/Cip1, resulting in G1-phase cell cycle accumulation in a dose-dependent manner [78].