Consistent with our results, NQO1 promotes an aggressive phenotype in hepatocellular carcinoma by amplifying ERK-NRF2 signaling [72]; immunohistochemical analysis showed that the protein levels of NRF2 and NQO1 were higher in carcinoma tissues than in benign follicular adenomas and hyperplastic nodules [73]. This evidence concerns the gene NQO1 and hepatocellular carcinoma.