TRPA1 and mitochondrial DNA depletion syndrome 4a: This is the first study to systematically evaluate cytotoxicity and TRPA1 activation in A549 cells induced by AHs (propanil, propisochlor, metolachlor, alachlor, acetochlor, pretilachlor, and butachlor), revealing that the TRPA1 channel is a potential common target for AHs poisoning, inducing a series of intracellular cascades mediated by calcium influx that result in cytotoxic damage.