An increased C-reactive protein (CRP) or accelerated erythrocyte sedimentation rate (ESR) (p = 0.03549) were cofactors affecting the development of CADR, while leukocytosis (p = 0.04404), eosinophilia (p = 0.00000), elevated liver parameters (p = 0.04841), and impaired renal parameters (p = 0.00012) were concomitant symptoms with high statistical significance. The gene discussed is CRP; the disease is Increased total leukocyte count.