AKT1 and cancer: Apoptosis was induced by DHA, and in a lesser extent by EPA, in cancer cells through impairment of the activity of protein kinase, Akt/PKB; p53 activation; increased caspase-3, caspase-9, and Bax pro-apoptotic enzyme levels or activity; and decreased survival and Bcl-XL, with DHA or EPA concentration ranging from 10 to 200 μM (reviewed in: [16,21]).