Overexpression of NF-κB(p65), SHh and GLI1 was observed in aggressive PCa tissue cores featuring high Gleason score and advanced clinical stage and was correlated with worse PFI, corroborating the clinical relevance of the NF-κB(p65)-SHh-GLI1 axis in advanced PCa. The gene discussed is GLI1; the disease is posterior cortical atrophy.