SCN8A and epilepsy: Notably, these data show that CaMKII inhibition of the R850Q mutant channel produces similar effects to that of the WT Nav1.6 channel, resulting in reduced current density and a right shift in the voltage-dependence of channel activation, and they suggest that CaMKII inhibition could help mitigate the impact of some gain-of-function effects imparted by epilepsy mutations.