These include, for instance, age and gender, diabetes, family history, hypertension and hypercholesterolemia, all of which are associated with a quantitative reduction and functional inhibition of PCs (both mature, i.e., CD34+/CD133+/KDR+, and less mature, i.e., CD34+) [55,57,58,59,60]. The gene discussed is CD34; the disease is Hypercholesterolemia.