The IP administration of BMS3 to 4T1.2 or MDA-MB-231 xenografted mice had no effect on primary tumor growth, and even increased metastasis in the liver, diaphragm, spleen, cecum, and stomach, although its half-time was quite high (5.6 h) and phospho-cofilin levels were reduced by 60% in the primary tumors [43]. This evidence concerns the gene CFL1 and neoplasm.