APOE and Alzheimer disease: A recent study by Srinivasan et al. (2020) also characterized a human Alzheimer’s microglia (HAM) profile from frozen postmortem brain tissue using bulk RNA-seq and identified similar profiles between DAM and HAM genes, particularly in AD risk factor genes involved in lipid transport and lysosome biology such as APOE, CLU, PLCG2 [283].