Cases of congenital hypopituitarism are, therefore, diagnosed during the neonatal period, most commonly with the clinical picture of hypoglycemia, due to GH and ACTH/cortisol deficiency, protracted jaundice, due to TSH/thyroxine and cortisol deficiency and, especially in males, micropenis, due to GH and gonadotrophin deficiencies. The gene discussed is GH1; the disease is hyperinsulinemic hypoglycemia, familial, 4.