MCOLN1 and coronary artery disorder: Of note, TFEB was reported as a positive regulator of angiogenesis through the activation of AMPKα and autophagy via the TFEB-dependent transcriptional upregulation of MCOLN1 (mucolipin-1) in the mouse hindlimb ischemia model [155], which implies its potential cardioprotective role in ischemic heart disease.