AGER and diabetes mellitus: Liu et al. reported that MGO (methylglyoxal), a metabolite of glycolysis, which was upregulated in diabetic patients, exhibited reduced endothelial angiogenesis through the receptor for advanced glycation end products (RAGE)-required, peroxynitrite (ONOO)-mediated, and autophagy-triggered VEGFR2 degradation, which might represent a novel mechanism for DM-associated angiogenesis abnormalities [156].