CASP1 and age-related macular degeneration: In the No AMD vs AMD groups, exceptions included a larger increase in Aim2 content in No AMD cells compared to AMD cells with rotenone treatment (p = 0.10; Figure 6A), a larger increase in Pro-Caspase-1 content in AMD cells compared to No AMD cells with ATP treatment (p = 0.02; Figure 6B), and a 4-fold increase in Cleaved Caspase-1 in AMD cells compared to no response in No AMD cells with Bafilomycin treatment (p = 0.08; Figure 6C).