Other reports investigating the role of inflammasome in the pathogenesis of AMD observed an increased content of NLRP3, ASC, Caspase-1, IL-1β, and IL-18 protein in RPE tissue from the macula region of donors with geographic atrophy (GA) compared to non-diseased controls [23,24,25]. The gene discussed is CASP1; the disease is age-related macular degeneration.