In the prostate tissues resected with thulium laser from BPH patients, 70 kDa HSP72 can stimulate ROS generation and upregulate NOD-like receptor (NLR) to activate the ROS-NLRP3 signaling pathway, thereby inducing sterile inflammation in the prostate glands [20]. The gene discussed is HSPA1A; the disease is benign prostatic hyperplasia.