Aside from mitochondrially directed deacetylase activity, SIRT6 depletion was found to downregulate multidrug resistance protein 1 (MDR1) expression through the suppression of CCAAT/enhancer-binding protein (C/EBPβ), promoting enhanced chemosensitivity to HCC [197]. This evidence concerns the gene ABCB1 and hepatocellular carcinoma.