To determine whether the presence of LMO2 is required for the activation of STAT3 in GSCs and GBM cells, we depleted LMO2 expression levels by transducing an LMO2-specific small hairpin RNA (shRNA) lentiviral vector and found that phosphorylated STAT3 was decreased by LMO2 depletion in GSCs (Figure 1C). Here, STAT3 is linked to glioblastoma.