Most studies have focused on the transcriptional role of LMO2 within the nucleus, whereas few studies have shown the presence of cytoplasmic LMO2 in vitro and in vivo, suggesting the potential tumor-suppressive functions of LMO2 in the cytoplasmic compartment by suppressing Wnt signaling via interaction with DVL-1/2 [25]. The gene discussed is LMO2; the disease is neoplasm.