Whereas psoriasis and many other cutaneous inflammatory diseases are not associated with skin fibrosis, accumulating data show that multiple ECM components, such as fibronectin, tenascin-C, and periostin, are upregulated or dislocated in the skin of psoriasis and AD patients and may contribute to keratinocyte hyperproliferation and the production of pro-inflammatory cytokines [33,34,35,36,37,38,39]. Here, POSTN is linked to Alzheimer disease.