GLP-1RAs have emerged as promising therapeutic candidates for tackling neuronal loss and neuroinflammation since GLP-1 signalling seems to have beneficial effects on several factors implicated in the pathogenesis of neurodegenerative diseases, e.g., ER stress, impaired redox homeostasis, autophagy and chronic inflammation (reviewed in [2,4,17,22,50,51,52]). The gene discussed is GLP1R; the disease is neurodegenerative disease.