CREB overexpression has been found in solid tumors such as non-small-cell lung carcinoma (NSCLC), glioblastoma, breast carcinoma, melanoma, and diffuse malignant mesothelioma [94,95,96,97,98,99,100,101,102,103,104,105] as well as hematological malignancies [106,107,108,109]. This evidence concerns the gene CREB1 and melanoma.