As mentioned previously, patients with FL-HCC were found to have an in-frame fusion of DnaJ homolog subfamily B member 1 (DNAJB1) and PKA Cα (DNAJB1-protein kinase cAMP-activated catalytic subunit alpha (PRKACA)), which led to increased PKA activity because the catalytic subunit was overexpressed [61]. This evidence concerns the gene DNAJB1 and hepatocellular carcinoma.