Given the ALDH1B1-driven cell cycle attenuation at the G2/M phase, and chemoresistance against DNA-damage agents previously observed in human colorectal adenocarcinoma cells [2], we hypothesize that ALDH1B1 plays an important role in DDR mechanisms and the development of colon cancer. The gene discussed is ALDH1B1; the disease is malignant colon neoplasm.