In the present study, we tested this hypothesis by utilizing an isogenic cell line pair of human colorectal adenocarcinoma cells (HT29), differing only in the ALDH1B1 expression previously established by lentiviral stable transfection [2], and publicly available data on colon or rectal adenocarcinoma clinical samples [16,17]. This evidence concerns the gene ALDH1B1 and colorectal adenocarcinoma.