NLRP3 and atherosclerosis: Since all the above-mentioned inflammatory signaling pathways particularly TLR, NF-κB, and NLRP3 activation have been shown by us and others to be major drivers of atherosclerosis disease progression and atherosclerosis pathology [13,14,15,16] on one hand and considering the involvement of Peli1 in their regulation, we investigated how Peli1 deficiency in an advanced model of atherosclerosis affects atherosclerosis disease progression.