In the present model of atherosclerosis, hypercholesteremia in Peli1-deficient mice reduced the percentage of FO B cells in the lymph nodes of Peli1 deficient mice, while in line with the previous findings the systemic level of IgG2a has been significantly elevated in Apoe−/−Peli1−/− mice fed HCD. This evidence concerns the gene PELI1 and atherosclerosis.