APOE and atherosclerosis: Furthermore, the systemic concentration of chemokines like GRO-α, MCP-1, and IP-10 (CXCL10) shown to contribute positively to the initiation and progression of atherosclerosis were increased systemically in Apoe−/−Peli1−/− mice versus Apoe−/− mice in advanced atherosclerosis (Figure 6g–i).