Since all the above-mentioned inflammatory signaling pathways particularly TLR, NF-κB, and NLRP3 activation have been shown by us and others to be major drivers of atherosclerosis disease progression and atherosclerosis pathology [13,14,15,16] on one hand and considering the involvement of Peli1 in their regulation, we investigated how Peli1 deficiency in an advanced model of atherosclerosis affects atherosclerosis disease progression. The gene discussed is PELI1; the disease is atherosclerosis.