RIGI and leishmaniasis: In addition, the analysis of KEGG signaling pathways enrichment for excessive expression of RIG-I indicated several positive regulations of the pertussis pathway, calcium signaling pathway, leishmaniasis pathway, and arachidonic acid metabolism pathway (Figure 10A); it also indicated several negative regulations of the Jak-STAT signaling pathway, protein digestion and absorption pathway, cGMP-PKG signaling pathway, allograft rejection pathway, PI3K-AKT signaling pathway and neuroactive ligand-receptor interaction pathway (Figure 10B).