Thus far, the most prominent functional significance of mammalian TPCs has been their involvement in endolysosome trafficking, including regulation of autophagy flux and macropinocytosis [13,14,15], nutrient sensing regulated through the mammalian target of rapamycin (mTOR) [16], and cellular infection of virulent viruses, such as Ebola virus and SARS-CoV-2 [17,18]. This evidence concerns the gene MTOR and infection.