Previous work demonstrated that both acute and chronic DOX-induced cardiomyopathies are associated with an accumulation in the mouse heart of Microtubule-associated protein 1A/1B-light chain 3b (Lc3b), a key marker of autophagosomes, as a result of the inhibition of the late phase of autophagic flux, i.e., the fusion of the autophagosome with lysosome and lysosomal vesicle degradation [87]. This evidence concerns the gene MAP1LC3B and cardiomyopathy.