GM130 is strongly up-regulated in gastric cancer and contributes to the gastric cancer cell migration and invasion by stimulating the transcription of the Snail gene, thus inducing the epithelial to mesenchymal transition (EMT) characterized by decreased expression of E-cadherin epithelial marker and increased expression of N-cadherin and vimentin mesenchymal markers [26]. The gene discussed is CDH1; the disease is gastric cancer.