RKTG/PAQR3 forms a protein complex with Twist1 and BTRC, the E3 ubiquitin ligase of Twist1, hence enhancing the interaction between Twist1 and BTRC, which promotes BTRC-mediated Twist1 polyubiquitination, its translocation from the nucleus to the proteasome-containing structure in the cytoplasm and its degradation, thus leading to the suppression of both gastric cancer cells in vitro EMT phenotype and migration and in vivo metastases [70]. This evidence concerns the gene TWIST1 and gastric cancer.