RKTG/PAQR3-mediated inhibition of Raf/MEK/ERK cascade (exemplified by decreased protein expression levels of Raf-1, p-MEK1 and p-ERK1/2) impairs EMT and, consequently, in vitro cell migration and invasion of esophageal cancer cells and laryngeal squamous cell carcinoma cells [63,64,65,66]. The gene discussed is MAP2K7; the disease is esophageal cancer.