RKTG/PAQR3 overexpression in melanoma cells harboring the oncogenic mutation of B-Raf (V600E) sequestrates mutated B-Raf to the GC, thus impairing the Ras/Raf/MEK/ERK cascade and, consequently, the in vitro and in vivo melanoma cell proliferation and tumorigenicity [71]. This evidence concerns the gene BRAF and melanoma.