RKTG/PAQR3 suppresses EMT phenotype, migration and invasion of multiple cancer cells (including gastric cancer, prostate cancer and glioma cells) by inhibiting not only Ras/Raf/MEK/ERK signaling but also the PI3K/AKT pathway by trapping to the GC key players in these cascades [67,68,69]. The gene discussed is AKT1; the disease is central nervous system cancer.