The TMED3-mediated IL-11 increased expression causes the IL-11-enhanced secretion, which, in turn, stimulates the phosphorylation of Signal transducer and activator of transcription 3 (STAT3), thus suggesting that TMED3 promotes HCC metastases through activating the IL-11/STAT3 signaling pathway [54]. The gene discussed is STAT3; the disease is hepatocellular carcinoma.