While upon KRAS silencing and exposure to FibCM, HCT116 cells show a significant downregulation of Rap-1 signaling (an important signaling pathway in cancer aggressiveness, involved for instance in epithelial to mesenchymal transition, invasion, and angiogenesis promotion [38]), LS174T cells upregulate proteins that are involved in adhesion and positive cell spreading regulation. The gene discussed is KRAS; the disease is cancer.