For example, in the chronic puromycin aminonucleoside (PAN) model of adaptive FSGS in Sprague Dawley rats, there are marked increases in glomerular TRPC6 abundance [18] that result in markedly elevated cation currents in podocytes in situ when these currents are evoked by membrane stretch [1]. This evidence concerns the gene TRPC6 and focal segmental glomerulosclerosis.