miR-4521 inhibited by the ETS proto-oncogene 1 (ETS1) targets both insulin = like growth factor 2 (IGF2) and forkhead box M1 (FOXM1) to inhibit Akt/GSK3β/Snai1 pathway proteins, and achieves inhibition of gastric cancer cell metastasis in hypoxia-induced conditions [107]. Here, FOXM1 is linked to gastric cancer.