For example, indirect co-culture with KPC mice-derived PDAC cells or treatment with tumor-conditioned media promoted iCAF differentiation from PSCs with the rapid phosphorylation of the RELA proto-oncogene, NF-kB subunit (RELA), whereas the treatment of an NF-κB inhibitor attenuated the iCAF-associated gene expression phenotypes [41]. Here, NFKB1 is linked to neoplasm.