CD8A and neoplasm: In addition, FAK inhibition has increased CD8+ T cell infiltrates and reduced the number of fibroblast activation protein α (FAP)-expressing fibroblasts, myeloid-derived suppressor cells (MDSCs), macrophages, and regulatory T cells (Tregs) within mice tumor tissues, suggesting the promising role of FAK pathway inhibition in reprogramming PDAC stroma to abrogate immunotherapy resistance [66].