[32] In this context, Silvestri et al. previously showed that BRCA1/2-positive mBCs were more likely to be ER-positive, PR-positive, and non-triple negative, compared with BC in female BRCA1/2 carriers, suggesting that susceptibility to hereditary BC may be influenced by hormonal background differences between male and female BRCA1/2 mutation carriers [12]. This evidence concerns the gene ESR1 and breast cancer.