A statistically significant association between BC/OC FH and the occurrence of PVs was found the BRCA2 gene (128/460 (27.8%) vs. 14/146 (9.6%), OR = 3.63, 95% CI = 1.99–7.08, Fisher’s exact test p < 10−5) and for the BRCA1 gene (26/460 (5.6%) vs. 2/146 (1.4%), p = 0.04). This evidence concerns the gene BRCA2 and breast cancer.