TF and neoplasm: Supportively, independent sets of data including ours, show, on one hand, that EMT-shifted CTCs represent a subpopulation of CTCs with enhanced metastatic competence [5,11,12,13] and, on the other hand, that TF-dependent coagulant properties of tumor cells facilitate their survival in the blood stream and metastatic colonization [15,21,22,68].