Approximately 20% of children with TAM progress to Acute Myeloid Leukemia (AML) [1,2,3,4,5,6,8,9,11] when persistent GATA1 mutant cells acquire additional mutations, most frequently in genes encoding members of the cohesin protein family, epigenetic regulators and signaling molecules [20,21]. Here, GATA1 is linked to acute myeloid leukemia.