As expected, 95% were younger than four years of age [6,8,9,14,19,24,27,29,30,32,33,35,37,42,57,58,59], almost none (4.8%) had CNS involvement at diagnosis [29,30,33,34,37,58,59], only 6 (14.6%) presented with immunophenotype other than Fab M7 (sporadic AML-DS) [15,27,30,33,34,35,37,57,59] and GATA-1 was mutated in 93.8% of ML-DS cases [42]. Here, GATA1 is linked to acute myeloid leukemia.