IGFBP2 and urinary bladder cancer: They also observed that circCDYL interacts with IGFBP1 and IGFBP2 in bladder cancer cell lines and that depletion of either circCDYL or those RBPs was a hallmark of cancer gene sets and knockdown of this circRNA affected the expression of TP53 and MYC, two important genes associated with tumor progression [22].