CCND1 and renal cell carcinoma: Wang et al. [78] observed that when used against ACHN, 786-O, and OS-RC-2 RCC cell lines, umbelliferone inhibited cell proliferation by inducing G1 cell cycle arrest, increasing Bax protein and decreasing Ki67, MCM2, Bcl-2, cyclin-dependent kinase 2 (CDK2), cyclin E1, CDK4, and cyclin D1 protein levels.