Park et al. [50] found that dicoumarol decreased cell viability in the ACHN, A-498, and Caki RCC cell lines and downregulated Bcl-2 (via inhibition of NF-κB and cyclic-AMP response element-binding protein), Mcl-1, and c-FLIP expression in Caki cells. This evidence concerns the gene CFLAR and renal cell carcinoma.