In addition, HP triggered the up-regulation of four miRNAs (let-7f-5p, let-7i-5p, miR-146b-5p, and −185-5p) that modulate the CIITA expression and therefore the HLA−II expression, which resulted in the HP infection persistence and the risk of developing GC in HP-infected patients [81]. Here, CIITA is linked to gastric cancer.