HIF1A and cancer: PX-478 (s-2-amino-3-[4′-N, N, -bis (chloroethyl) amino] phenyl propionic acid N-oxide dihydrochloride) is a recently developed experimental anti-cancer drug that inhibits HIF-1α expression at multiple levels including decreasing mRNA levels and inhibition of HIF-1α translation [100,101,102].