Furthermore, the blockade of the menin-MLL1 interaction by the menin-MLL1 inhibitor VTP50469 hampers the chromatin binding of not only menin and MLL1 but also NUP98 fusion proteins, and it also inhibits leukemogenesis in models of NUP98-rearranged leukemias, including NUP98–KDM5A [83]. Here, KMT2A is linked to leukemia.