Figure 2c represents the frequency of ER+ and ER- according to gBRCA1 or gBRCA2 carriage among unselected breast cancer patients. gBRCA1-ER+, gBRCA2-ER+, gBRCA1-ER-, gBRCA2-ER- status accounted for 17%, 41%, 28% and 14% of gBRCA breast cancers, respectively (Supplementary Materials, Table S2). Here, ESR1 is linked to breast cancer.