Then, we confirm the computational hypothesis: the downregulation of NRAS significantly decreases cell proliferation only in the NRAS-altered AML cell lines, and the inhibition of PTPN11 expression produces an equivalent effect, specifically in the NRAS-wt AML cell lines (Figure 4D), validating the predicted dLED. This evidence concerns the gene PTPN11 and acute myeloid leukemia.