The final overlapping protein, TNFRSF12A, also known as fibroblast growth factor-inducible 14 (Fn14), and its ligand, TWEAK, show low expressions in normal tissues; however, they have also been found to be highly expressed in several solid tumours and metastases, including pancreatic cancer cell lines [35,36]. The gene discussed is TNFSF12; the disease is pancreatic neoplasm.