In this line, the study performed by Zinnah et al. showed that amitriptyline could sensitize TRAIL-resistant A549 lung cancer cells to tumor-necrosis-factor-related apoptosis-inducing ligand (TRAIL) and enhance TRAIL-induced apoptosis through DR4 and DR5 upregulation and autophagy inhibition [74]. The gene discussed is TNFSF10; the disease is lung cancer.