STAT3 and colorectal cancer: Its anti-invasive and anti-cell-migration properties make imipramine an interesting drug candidate to halt metastasis and reduce tumor progression, not only against colorectal cancer but also against other invasive tumors; for example, cytokine-induced fascin expression is regulated by Signal Transducers and Activators of Transcription 3 (STAT3) and is required for breast cancer cell migration [119].