To date, a very recent meta-analysis [17] including four studies (three retrospective and one prospective cohort studies) with five cohorts and a total of 1254 BRCA1/2 mutated BC patients, concluded that BCT is associated with a significantly higher risk of local recurrence than mastectomy (HR 3.838, 95% CI = 2.376–6.201, p < 0.001). This evidence concerns the gene BRCA1 and breast cancer.