A recent population-based matched analysis by Hu et al. reported that among women with BC, the prevalence of 12 established BC-predisposition genes (ATM, BARD1, BRCA1, BRCA2, CDH1, CHEK2, NF1, PALB2, PTEN, RAD51C, RAD51C, and TP53) is close to 5% [26]. The gene discussed is PTEN; the disease is breast cancer.