While BRCA1 and BRCA2 are the most frequently mutated genes in families with a high risk of breast and ovarian cancer, panel testing can identify less common syndromes that can also confer hereditary cancer risks [34,35,36,37,38,39,40], such as Li-Fraumeni syndrome (TP53 pathogenic variant), Cowden syndrome (PTEN pathogenic variant), Hereditary diffuse gastric cancer syndrome (CDH1 pathogenic variant), and Peutz-Jegher syndrome (STK11 pathogenic variant) [30]. This evidence concerns the gene TP53 and Li-Fraumeni syndrome.