Indeed, P or LP variants of other BC susceptibility genes, including high-penetrance genes such as CDH1, PALB2, PTEN, STK11, and TP53, and moderate-penetrance genes such as ATM, CHEK2, NBN, and NF1, also confer an increased BC risk [9,22,23,25,27]. The gene discussed is CHEK2; the disease is breast cancer.