Interestingly, in 2019, a cohort of 6484 women who had been diagnosed with invasive BC at <50 years and treated between 1970 and 2003 in 10 Dutch centers, was analyzed with the objective of investigating the effects of different types of surgery on BC prognosis in germline BRCA1/BRCA2 mutation carriers compared with non-carriers [90]. This evidence concerns the gene BRCA2 and breast cancer.