BRCA1 and breast cancer: Moreover, a multi-institutional retrospective analysis by Bernstein-Molho and colleagues reported higher rates of new primary BC in BRCA-associated BC patients treated with BCT than in those treated with mastectomy, although there were no differences in regional or distant recurrences or in overall survival, suggesting BCT is an acceptable alternative to mastectomy in the treatment of BRCA1/2-associated BC, despite the higher lifetime risk of developing BC [92].