BRCA2 and Inherited cancer-predisposing syndrome: More recently, data from a large international consortium of families with hereditary cancer syndromes associated with BRCA germline mutations demonstrated that the relative risk (RR) of PDAC was 2.36 (95% CI, 1.51–3.68) for BRCA1 and 3.34 (95% CI, 2.21–5.06) for BRCA2.