BRCA1 and Inherited cancer-predisposing syndrome: Several studies have shown that 3.8% to 9.7% of patients with PDAC carry a pathogenic germline mutation in genes that predispose them to hereditary cancer syndromes, including familial atypical multiple mole melanoma (CDKN2A), Peutz-Jeghers (STK11), hereditary breast and ovarian cancer (BRCA1, BRCA2, PALB2, ATM), Lynch (MLH1, MSH2, MSH6), and Li-Fraumeni (TP53) syndromes [21,22,23,24,25,26,27,28].