In line with our results, these studies have shown that TP53 expression by IHC is strongly correlated with TP53 missense mutation detection but, because prostate tumor tissues show low basal expression of TP53, IHC cannot detect p53 loss that results from nonsense/frameshift/indel alterations or copy number losses [9,26,27,28]. Here, TP53 is linked to prostate neoplasm.