We therefore set out to examine, in depth, correlations between protein expression (IHC), RNA expression (microarray) and DNA sequence (targeted sequencing) status of TP53, RB1 and PTEN, using a set of 28 patient tumor-derived xenograft (PDX) models, in an attempt to refine the definition of the AVPC-m and facilitate its implementation in clinical practice. This evidence concerns the gene PTEN and neoplasm.