The rescue effects of knocking-down or overexpressing FOXO4 in TET1-modulated cells also showed in the expression of CSC and EMT markers (Figure 6E–H and Figure S8A,B), which further confirmed that TET1 suppresses cancer metastasis through decreasing the features of CSC and EMT by inhibiting Wnt signaling through transactivating FOXO4. The gene discussed is FOXO4; the disease is cancer.