Interestingly, knocking-down FOXO4 in TET1-overexpressing cells or overexpressing FOXO4 in TET1-knocking-down cells fully rescued the features of CSC and EMT in gastric cancer cells, suggesting that FOXO4 might be the major player downstream of TET1 to regulate metastasis-promoting Wnt signaling. Here, FOXO4 is linked to gastric cancer.