TP53 and neoplasm: In another study, Xiao et al. used an oncolytic adenovirus expressing the VEGF inhibitor VEGI-251 and demonstrated the induction of apoptosis and the inhibition of neovascularisation [114], while Wang et al., employing rAd-p53 carrying the promoter of early growth response (Egr-1), and the anti-apoptotic TNF-related apoptosis-inducing ligand (TRAIL) gene showed increased radiotherapy-induced apoptosis in cell lines and tumour size reduction in xenograft mice [112].