TKT and leiomyoma: Furthermore, targeted and transduction-efficient Ads, such as Adenovirus-human somatostatin receptor subtype 2-arginine, glycine, and aspartate-thymidine kinase (Ad-SSTR-RGD-TK), given in combination with GCV, show promising results, both in vitro [177] and in vivo [178], as they lead to a significant reduction in proliferation and leiomyomas size, the induction of apoptosis, and the inhibition of angiogenic- and extracellular matrix-related genes.