In a different approach, Hampl et al. [30] constructed the adenoviral vector, Ad-hEndo, and used it to mediate the transfer of human endostatin (COL18A1) in ovarian cancer ascites in mice, demonstrating a significant down-regulation in ascites formation, reduced tumour growth and vascularity, as well as prolonged animal survival [30]. This evidence concerns the gene COL18A1 and ovarian cancer.