A few years later, Yang et al. overexpressed FRα, previously shown to be highly expressed in cervical cancer, using an FRα-targeted liposome (FLP) to deliver a pigment epithelium-derived factor (PEDF) gene into HeLa cells and observed significant anti-tumour activity, as demonstrated by significant growth inhibition, the suppression of adhesion and invasion, and cancer cell migration in vitro [130]. The gene discussed is SERPINF1; the disease is cervical cancer.