MACC1 and ovarian cancer: Specifically, Zhang et al. used an shRNA plasmid to knock-down MACC1 in ovarian carcinoma (OVCAR)-3 cells to demonstrate the inhibition of proliferation, migration, invasion, and induction of apoptosis both in vitro and in vivo in mouse models [67], while the siRNA interference strategy to knock-down MTA1 in ovarian cancer cell line A2780 resulted in reduced migration, invasion, and adhesion and increased apoptosis in vitro [68].