We noticed that MYCN-amplified neuroblastoma cells exhibited a significant vulnerability to VLX600, with an IC50 206 ± 9 nM in IMR-32 cells and IC50 326 ± 37 nM in Sk-N-BE(2) cells compared with that in human colon tumor cells (IC50 ~ 6.5 μM) (Figure 2A,B). The gene discussed is MYCN; the disease is neuroblastoma.